Ki-67 and bromodeoxyuridine labeling of human choroidal melanoma cells
作者:
BardensteinDavid S.,
CharDevron H.,
KaletaShawnya,
KrollStewart M.,
期刊:
Current Eye Research
(Taylor Available online 1991)
卷期:
Volume 10,
issue 5
页码: 479-484
ISSN:0271-3683
年代: 1991
DOI:10.3109/02713689109001755
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Understanding tumor growth patterns has implications for prognosis as well as for response and susceptiblity to treatment. The antibody Ki-67 was used as a marker of cycling cells and bromodeoxyuridine (BrdUrd) was used as a marker of proliferating cells to characterize the cycling and proliferative rates of cells from human choroidal melanoma. The BrdUrd labeling indices varied from 0–1.1% and the Ki-67 labeling indices ranged from 0–3.03%. Linear regression modeling showed good correlation defined by the equation: Ki-67 index−0.237 + 1.63×BrdUrd labeling index with r = 0.919. Correlations between these indices and clinical and histologic parameters were not significant.
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