Extravasation is a dreaded complication of the administration of vesicant antineoplastic drugs. While the reported incidence of extravasation is relatively low,1the effects of infiltration with a vesicant can be severe. The damage can be as minor as a local erythema or as catastrophic as gangrene, necessitating amputation. This article discusses the role of the I.V. nurse in minimizing the harmful effects of vesicant extravasation.