L-Phenylalanine and UVA Irradiation in the Treatment of Vitiligo
作者:
A.H. Siddiqui,
L·M.L. Stolk,
R. Bhaggoe,
R. Hu,
R.B.H. Schutgens,
W. Westerhof,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 3
页码: 215-218
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247142
出版商: S. Karger AG
关键词: L-Phenylalanine;PheUVA therapy;Photochemotherapy;Vitiligo
数据来源: Karger
摘要:
In order to evaluate the efficacy of L-phenylalanine (L-Phe) in combination with UVA therapy for vitiligo an open trial (149 patients, 18 months) and a small double-blind trial (32 patients, 6 months) were conducted. Oral L-Phe loading resulted in peak plasma levels of L-Phe after 30–60 min and a slight increase in the plasma tyrosine level. Response to L-Phe plus UVA irradiation was positive, and various grades of repigmentation not exceeding 77% in the open and 60% in the blind trial were observed. An increased L-Phe dose resulted in increased L-Phe plasma levels but not in improved clinical results. The optimal L-Phe dose appears to be lower than 50 mg/kg/day. Although it is difficult to draw firm conclusions from the present investigation, we think that L-Phe may have a place in the treatment of vitiligo and its role merits further investigatio
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