In vitro Comparative Activity of Moxalactam, GR 20263, and N-Formimidoyl Thienamycin to Other Beta-Lactam Antibiotics and Tobramycin against Enterobacteriaceae and Staphylococci
作者:
Michael H. Cynamon,
Paul A. Granato,
期刊:
Chemotherapy
(Karger Available online 1982)
卷期:
Volume 28,
issue 3
页码: 204-208
ISSN:0009-3157
年代: 1982
DOI:10.1159/000238077
出版商: S. Karger AG
关键词: Moxalactam;GR 20263;N-formimidoyl thienamycin;Cephalosporins;Beta-lactams;Tobramycin;Enterobacteriaceae;Staphylococci
数据来源: Karger
摘要:
The in vitro activities of moxalactam, GR 20263, and N-formimidoyl thienamycin were compared to those of cephalothin, cefazolin, cefamandole, cefoxitin, and tobramycin against 152 strains of Enterobacteriaceae and staphylococci. The results showed that moxalactam, GR 20263, and N-formimidoyl thienamycin each had significantly improved activity toward the gram-negative organisms tested compared to the other β-lactams and tobramycin. N-formimidoyl thienamycin was particularly impressive with respect to its activity toward Staphylococcus auteus and S. epidermidis as compared to moxalactam, GR 20263 and the older β-lactam drug
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