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Loss of synapses in the dentate gyrus of the senescent rat

 

作者: William Bondareff,   Yuri Geinisman,  

 

期刊: American Journal of Anatomy  （WILEY Available online 1976）
卷期: Volume 145, issue 1  

页码: 129-136

 

ISSN:0002-9106

 

年代: 1976

 

DOI:10.1002/aja.1001450110

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

数据来源: WILEY

 

摘要:

AbstractSynapses were counted in electron micrographs of the middle third of the molecular layer of the dentate gyrus of Fischer 344 rats, 3 months and 25 months of age. A 27% decrease in the number of synapses was found in senescent animals compared with young adults. This loss of synapses could not be correlated with changes in synaptic size, tissue volume or number of postsynaptic granule cells.

 

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