Spectrophotometric Determination of Metformin via Charge-Transfer Complex with Iodine
作者:
MohamedG. El-bardicy,
SoniaZ. El-khateeb,
AbdelkaderS. Ahmad,
HodaN. Assaad,
期刊:
Spectroscopy Letters
(Taylor Available online 1989)
卷期:
Volume 22,
issue 9
页码: 1173-1181
ISSN:0038-7010
年代: 1989
DOI:10.1080/00387018908054014
出版商: Taylor & Francis Group
关键词: Metformin;Determination;Spectrophotometry
数据来源: Taylor
摘要:
A spectroscopic method is described for the determination of Metformin based on its formation of molecular complex with iodine in dichloroethane. Quantitative measurements are made at the maximum absorption of 295nm. The molar ratio of the formed metformin-iodine complex is 1:1 as revealed by Job's method. Beers' law is obeyed in the range 2–12 ug.ml−1base solution. The proposed method is statistically comparable with the official B. P. method. When applied to pharmaceutical preparation, tablets, average percentage recovery of 99.97 ± 0.81 was obtained.
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