Chemical reactions and physical processes occurring during matrix devitrification are studied to reveal important factors concerning low-temperature, isotropic, amorphous structures. Reactions in this regime allow active observation of supercooled reagents well below their melting temperatures. It is possible to selectively carry out and observe chain reactions in the vitrifying matrix, whereas in crystal lattices such reactions are hindered due to low translational reagent mobility effects. Very low-temperature reactions allow selectivity of pathways in the vitrifying medium; entropy effects are minimized and exothermic pathways are favoured.