Effects of Flavonoids ofGinkgo bilobaon Proliferation of Human Skin Fibroblast
作者:
Seong-Jin Kim,
Mi-Hye Lim,
Inn-Ki Chun,
Young-Ho Won,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1997)
卷期:
Volume 10,
issue 4
页码: 200-205
ISSN:1660-5527
年代: 1997
DOI:10.1159/000211505
出版商: S. Karger AG
关键词: Ginkgo biloba;Fibroblast;proliferation;Flavonoids
数据来源: Karger
摘要:
Ginkgo bilobα studies have focused on the anti-inflammatory effects of the major components, ginkgolide and bilobalide, whereas little is known about their effect on fibroblasts. This study demonstrated the enhancing effects of Ginkgo L. extracts, especially the fiavonoid fractions: quercetin, kaempfe-rol, sciadopitysin, ginkgetin, isoginkgetin, on the proliferation of normal human skin fibroblast in vitro measured by MTT (3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide) assay and direct hemocytometer cell count. Furthermore, increased production of collagen and extracellular fi-bronectin were documented by radioisotope (2,3-3H-proline) incorporated collagen assay, procollagen type I C-peptide assay and by immunoturbidimetric assay. These proliferative effects suggest another useful pharmacologic application of Ginkgo L. extracts in addition to their well-known anti-inflammatory effect
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