Participation of Neural Crest Cells in Cardiovascular Morphogenesis of Chick Embryos
作者:
Kunio HAYAKAWA,
Takahiro OKISHIMA,
Kazushi TAKAMURA,
Shozo OHDO,
期刊:
Congenital Anomalies
(WILEY Available online 1991)
卷期:
Volume 31,
issue 1
页码: 1-12
ISSN:0914-3505
年代: 1991
DOI:10.1111/j.1741-4520.1991.tb00353.x
出版商: Blackwell Publishing Ltd
关键词: neural crest cell;cardiovascular anomalies;persistent truncus arteriosus;congenital malformation syndrome;bis‐diamine
数据来源: WILEY
摘要:
AbstractNeural crest cells appear on top of the neural folds at closure of the neural tube. These cells are capable of migrating and differentiating into multiple tissues. In 1983, Kirby et al., using chimera methodology, reported that cranial neural crest cells participated in aorticopulmonary and truncal septation. Since that time, many experimental studies have been done in this field. In this paper, we report new experimental findings and review four areas of study on neural crest cells, i.e. their general characteristics, participation of neural crest cells in formation of the normal heart, cardiovascular anomalies due to ablation of the neural crest cells, and the relationship between neural crest cells and congenital malformation syndromes, especially the DiGeorge sequence.
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