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Synthesis of an analogue of α‐MSH‐(1–10)‐decapeptide as a substrate for enzymatic Nα‐acetylation

 

作者: H.P.C. DRIESSEN,   H. BLOEMENDAL,   W.W. JONG,   G.I. TESSER,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1982）
卷期: Volume 20, issue 4  

页码: 289-297

 

ISSN:0367-8377

 

年代: 1982

 

DOI:10.1111/j.1399-3011.1982.tb00893.x

 

出版商: Blackwell Publishing Ltd

 

关键词: t‐butylation;enzymatic N α‐acetylation;α‐MSH‐(1–10)‐decapeptide analogue;norleucine;substrate

 

数据来源: WILEY

 

摘要:

The synthesis of a stable substrate for enzymaticNα‐acetylation is described. To this end an analogue of α‐MSH‐(1–10)‐decapeptide with norleucine instead of methionine at position 4 is prepared. t‐Butylation of an intermediate Z‐Tyr‐OMe leads only to about 75% conversion in a few hours' reaction time, and cannot be carried to completion. The [Nle4]‐decapeptide is as good a substrate for enzymaticNα‐acetylation as the original decapeptide

 

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