Characterization of the Amyloid Fibril from Primary Localized Cutaneous Nodular Amyloidosis Associated with Sjögren’s Syndrome
作者:
T. Inazumi,
M. Hakuno,
H. Yamada,
M. Tanaka,
W. Naka,
S. Tajima,
T. Harada,
T. Nishikawa,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 189,
issue 2
页码: 125-128
ISSN:1018-8665
年代: 1994
DOI:10.1159/000246814
出版商: S. Karger AG
关键词: Cutaneous amyloidosis;Polyclonal immunoglobulins;Sjögren’s syndrome
数据来源: Karger
摘要:
Background: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown. Objective: The purpose of this study was to know the origin of amyloid in PLCNA. Methods: Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis. Results: The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-λ- and anti-K-light-chain antibodies. Conclusion: Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones
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