Serum IgG Antibodies to Gliadin in Children with Celiac Disease as Measured by an Immunofluorescence Method
作者:
Shraga,
Blazer Yehezkel,
Naveh Moshe,
Berant David,
Merzbach Shoshana,
期刊:
Journal of Pediatric Gastroenterology and Nutrition
(OVID Available online 1984)
卷期:
Volume 3,
issue 2
页码: 205-209
ISSN:0277-2116
年代: 1984
出版商: OVID
关键词: Celiac disease;Fluorescence antibody technique;Gliadin;Immunology
数据来源: OVID
摘要:
Antigliadin antibodies (AGAs) were studied in sera from 190 patients divided into five clinical groups. Group I included 28 sera from children with newly diagnosed celiac disease on a normal diet. Group II consisted of 43 sera from children with celiac disease who were fed a gluten-free diet (GFD). Group III included 25 sera from children with celiac disease who had been in remission but exposed to a gluten-containing diet (GCD). Group IV consisted of 46 sera from children with chronic diarrheal disorders other than celiac disease. Group V included 43 sera from healthy children. The observed p values proved that (a) mean titer levels of AGAs in Groups I and III were significantly higher than the mean values for all other groups (p < 0.001), and (b) the mean titer level of AGAs in Group II was significantly higher than the mean values for Groups IV and V A good correlation between the AGA titers and the morphology of the duodenal mucosa was found in children with celiac disease. The examination of IgG AGAs by the immunofluorescence technique used in our study appears to be a useful tool in the follow-up of individual patients to determine adherence to a GFD.
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