Expression of Intercellular Adhesion Molecule-1 and Infiltration of Lymphocytes in Glomeruli of Patients with IgA Nephropathy
作者:
Yasuhiko Tomino,
Hiroyuki Ohmuro,
Takao Kuramoto,
Isao Shirato,
Kazuhiko Eguchi,
Hideto Sakai,
Ko Okumura,
Hikaru Koide,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 3
页码: 302-307
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187984
出版商: S. Karger AG
关键词: ICAM-1;Lymphocytes;Glomerular injuries;IgA nephropathy
数据来源: Karger
摘要:
Using immunofluorescence, we studied 19 patients with IgA nephropathy to determine whether the expression of intercellular adhesion molecule (ICAM)-l in glomeruli might reflect the disease activity. The relationship between the expression of ICAM-1 and the infiltration of lymphocytes, monocytes and polymorphonuclear leukocytes (PMN) in glomeruli of IgA nephropathy cases was examined. The expression of IC AM-1 in patients in the advanced stage was significantly higher than that in patients in the mild stage. In double immunofluorescence, the distribution of ICAM-1 expression in glomeruli was different from that of IgA deposition in patients in both stages. Glomeruli which showed increases of ICAM-1 expression had marked infiltration of lymphocytes (OKT4+, OKT8+ T cells), and monocytes (OKM1+ cells). Increase of urinary protein and decreases in renal function were observed in patients in the advanced stage. It appears that the expression of ICAM-1 is closely linked to glomerular cell proliferation, and infiltration of lymphocytes and monocytes in patients with IgA nephropathy. However, the expression of ICAM-1 in glomeruli might not be correlated with IgA-dominant immune complexes in this disease.
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