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Study of the Effects of Certain Drugs on Experimental Porphyria in Rats

 

作者: S.G. Deshpande,   K.C. Kandhari,   B.S. Narang,   R. Bikhchandani,   L.K. Bhutani,  

 

期刊: Dermatology  （Karger Available online 1977）
卷期: Volume 154, issue 5  

页码: 284-290

 

ISSN:1018-8665

 

年代: 1977

 

DOI:10.1159/000251083

 

出版商: S. Karger AG

 

关键词: Porphyria;3;4-Diethoxycarbonyl-1;4-dihydrocollidine;Long-term experiments;Drug sensitization;Phenobarbitone;Chloroquine;Alcohol;Griseofulvin

 

数据来源: Karger

 

摘要:

The effect of ethanol, phenobarbitone, griseofulvin or chloroquine on 3,4-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria in rats has been studied in experiments lasting up to 40 days. Ethanol, phenobarbitone or griseofulvin given later, in addition to DDC, resulted in a clearly greater porphyrin excretion and liver porphyrin concentration than with DDC alone. Chloroquine at first increased, then decreased porphyrin excretion and liver porphyrin was lowered. No drug without DDC was porphyrogenic.

 

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