Co-Stimulatory Blockade and Tolerance Induction in Transplantation
作者:
Adam Bartlett,
John McCall,
Stephen Munn,
期刊:
BioDrugs
(ADIS Available online 2001)
卷期:
Volume 15,
issue 8
页码: 491-500
ISSN:1173-8804
年代: 2001
出版商: ADIS
关键词: Immune function;Immunosuppressants, pharmacodynamics;Transplant rejection
数据来源: ADIS
摘要:
Recipients of organ and tissue transplants require lifelong immunosuppression to prevent rejection. Better understanding of the processes culminating in allograft rejection has led to novel approaches to modulating the immune response. Co-stimulatory signals between antigen-presenting and -responding cells are essential for a normal alloimmune response, and blockade of these pathways during initial graft-host interaction may be used to ameliorate or prevent a destructive response from proceeding. A large number of experimental studies now support this concept, and early clinical trials have been initiated. Despite some early difficulties and many unanswered questions, co-stimulatory blockade has major potential as a future immune-modulating mechanism for use in clinical transplantation.
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