首页   按字顺浏览 期刊浏览 卷期浏览 Roles of growth hormone and growth factors in the pathogenesis and treatment of kidney ...
Roles of growth hormone and growth factors in the pathogenesis and treatment of kidney disease

 

作者: Michael O'Shea,   Steven Miller,   Kevin Finkel,   Marc Hammerman,  

 

期刊: Current Opinion in Nephrology and Hypertension  (OVID Available online 1993)
卷期: Volume 2, issue 1  

页码: 67-72

 

ISSN:1062-4821

 

年代: 1993

 

出版商: OVID

 

数据来源: OVID

 

摘要:

Growth hormone and a number of polypeptide growth factors exert actions on renal development, growth, and metabolism and on repair processes following renal injury. There is increasing evidence that under selected circumstances, these agents play roles in the pathogenesis of kidney disease and that under others, they may be useful in its treatment. Growth hormone, platelet-derived growth factor, or transforming growth factor-β may be causative of glomerulosclerosis. The reduction in epidermal growth factor expression within the kidney in the setting of acute ischemic injury could delay regeneration, and replacement may be therapeutic. Insulinlike growth factor I may play a role in the regenerative response to acute renal injury. Pharmacologic properties of growth hormone or insulinlike growth factor I to enhance glomerular filtration rate and renal plasma flow and to increase skeletal growth may be harnessable for treating chronic renal failure and its complications. It is likely that strategies designed to employ growth hormone or growth factors as pharmacologic agents or to block their activities will assume increasingly important roles in therapy for renal disease.

 

点击下载:  PDF (602KB)



返 回