Vigabatrin in Childhood Epilepsy: Comparable Efficacy for Generalized and Partial Seizures
作者:
Raj Sheth,
David Buckley,
Sharon Penney,
Gerald Hobbs,
期刊:
Clinical Neuropharmacology
(OVID Available online 1996)
卷期:
Volume 19,
issue 4
页码: 297-304
ISSN:0362-5664
年代: 1996
出版商: OVID
关键词: Vigabatrin;Epilepsy;Seizures;Child;Antiepileptic drugs;Refractory.
数据来源: OVID
摘要:
Summary:Thirty‐one patients, aged 12.6 ± 5.6 years, with refractory seizures for 8 ± 4.3 years, were treated with adjunctive vigabatrin. Twenty‐four percent had a >50% reduction in seizure frequency (95% one‐sided confidence interval). Generalized myoclonic, atonic, and tonic clonic and partial, with and without secondary generalization, seizures were all reduced at a mean dose of 70 ± 38 mg/kg/day. Comparison of vigabatrin therapy duration, for partial and generalized seizure groups, utilizing Kaplan‐Meier methodology showed similar survival times. Vigabatrin therapy was ineffective in the four children with tuberous sclerosis. Transient somnolence, ataxia and dizziness were the most frequent side effects. A severe aggressive agitation occurred in three patients, and necessitated discontinuation of vigabatrin in one patient. Vigabatrin was as effective in generalized as in partial seizures in this study. Clinical utility may be limited by unacceptable behavioral side effects in some patients.
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