Drugs of Abuse and Brain Gene Expression
作者:
German Torres,
Judith Horowitz,
期刊:
Psychosomatic Medicine
(OVID Available online 1999)
卷期:
Volume 61,
issue 5
页码: 630-630
ISSN:0033-3174
年代: 1999
出版商: OVID
关键词: addiction;dopamine;genes;mutagenesis;rodents;striatum
数据来源: OVID
摘要:
Addictive drugs like cocaine, ethanol, and morphine activate signal transduction pathways that regulate brain gene expression. Such regulation is modulated by the presence of certain transcription factor proteins present in a given neuron. This article summarizes the effects of several addictive drugs on transcriptional processes contributing to the development of a drug-dependent state. The characterization of drug-induced changes in gene expression shows promise for improving our understanding of drug-addiction phenomena and cellular modes of cocaine, ethanol, and morphine action.
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