Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. V. Generation of hydroxyl radical by sporidesmin
作者:
R. Munday,
期刊:
Journal of Applied Toxicology
(WILEY Available online 1987)
卷期:
Volume 7,
issue 1
页码: 17-22
ISSN:0260-437X
年代: 1987
DOI:10.1002/jat.2550070105
出版商: John Wiley&Sons, Ltd.
关键词: sporidesmin toxicity;hydroxyl radical;superoxide radical;hydrogen peroxide;zinc
数据来源: WILEY
摘要:
AbstractSporidesmin, the mycotoxin responsible for ‘facial eczema’ in ruminants, has previously been shown to generate superoxide radical and hydrogen peroxide. In the present study, the formation of the third ‘active oxygen’ species, hydroxyl radical, has been demonstrated. This species is produced both during the autoxidation of the reduced (dithiol) form of the mycotoxin and in the cyclic reduction/autoxidation reaction between sporidesmin and glutathione. In view of the exceptional reactivity of the hydroxyl radical, this substance may be the proximate agent responsible for the toxic effects of spor
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