This article highligts some of the issues associated with the administration of cytotoxic chemotherapy agents. As can be seen, the practical aspects of drug preparation and administration, and the toxicities associated with these two drugs vary greatly (Table2), despite their structural similarities. The potential harm which can be caused by the administration of these drugs without a prior knowledge of these factors cannot be over emphasized. It is hoped that this and subsequent articles can provide some insight into the administration of such agents, but their safe administration is only really possible under the guidance of experienced personnel. Hopefully, this fact will be recognized and all hospitals where cytotoxic chemotherapy is administered will employ suitably trained health professional and pharmacists.