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Effect of Angiotensin Converting Enzyme Inhibition on Blood Pressure and Renal Function during Open Heart Surgery

 

作者: P. Colson,   J. Ribstein,   A. Mimran,   D. Grolleau,   P. Chaptal,   B. Roquefeuil,  

 

期刊: Anesthesiology  (OVID Available online 1990)
卷期: Volume 72, issue 1  

页码: 23-27

 

ISSN:0003-3022

 

年代: 1990

 

出版商: OVID

 

关键词: Kidney: renin-angiotensin system;Pharmacology: captopril;Surgery;cardiac: cardiopulmonary bypass

 

数据来源: OVID

 

摘要:

Activation of the renin-angiotensin system during open heart surgery may have consequences both beneficial in sustaining blood pressure and deleterious in compromising renal hemodynamics. The influence of short-term pretreatment with captopril on blood pressure and renal function was assessed double-blindversusplacebo in 18 patients without pre-existing cardiac or renal failure, and undergoing coronary artery bypass. No difference in blood pressure and fluid requirement during the surgical period was observed between groups receiving captopril or placebo. Effective renal plasma flow and glomerular filtration rate decreased in the placebo group whereas they remained unaltered in the captopril group; during cardiopulmonary bypass, urinary excretion of sodium was greater in patients receiving captopril than those receiving placebo. These results suggest that captopril pretreatment does not compromise the control of blood pressure and renal function during open heart surgery; additional studies on the protective value of angiotensin-converting enzyme inhibitors are warranted in patients at higher risk for developing renal failure.

 

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