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Use of Polymerase Chain Reaction nad Denaturing Gradient Gel Electrophoresis to Identify Polymorphisms in Three Exons of Dopamine D2Receptor Gene in Schizophrenic and Delusional Patients

 

作者: Marco Catalano,   Maria Nobile,   Emanuela Novelli,   Enrico Smeraldi,  

 

期刊: Neuropsychobiology  （Karger Available online 1992）
卷期: Volume 26, issue 1-2  

页码: 1-3

 

ISSN:0302-282X

 

年代: 1992

 

DOI:10.1159/000118888

 

出版商: S. Karger AG

 

关键词: DNA;Dopamine D2receptor gene;Polymorphisms;Schizophrenia;Delusional disorder;Polymerase chain reaction;Denaturing gradient gel electrophoresis

 

数据来源: Karger

 

摘要:

The dopamine D2 receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics, delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alterations in the DRD2 gene.

 

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