Expression of Galactose-1-Phosphate Uridyltransferase in the Anterior Pituitary of Rat during the Estrous Cycle
作者:
Nathalie Daude,
Jacques Lestage,
Jürgen K.V. Reichardt,
Klaus G. Petry,
期刊:
Neuroendocrinology
(Karger Available online 1996)
卷期:
Volume 64,
issue 1
页码: 42-48
ISSN:0028-3835
年代: 1996
DOI:10.1159/000127096
出版商: S. Karger AG
关键词: Galactosemia;Gonadotropes;Gonadotropins;Galactose-1-phosphate uridyl;Transferase;Estrous cycle
数据来源: Karger
摘要:
Biological activity of the follicle-stimulating hormone (FSH) is dependent on its pattern of glycosylation and is altered during galactosemia, a genetic disease characterized by deficient activity of galactose-1-phosphate uridyltransferase (GALT). To assess the role of this enzyme in the synthesis of FSH, the expression of GALT at the mRNA and protein levels was measured in the whole anterior pituitary during the estrous cycle of rat. GALT was maximally expressed during the proestrous and estrous phases of the estrous cycle. The expression pattern of GALT was associated with gonadotropin-expressing cells. This close association is in accordance with the postulated role of GALT in modulating biological activity of FSH.
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