Plasma and Blood Volumes in Patients with the Nephrotic Syndrome
作者:
A.B. Geers,
H.A. Koomans,
P. Boer,
Dorhout Mees,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 38,
issue 3
页码: 170-173
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183302
出版商: S. Karger AG
关键词: Nephrotic syndrome;Plasma volume;Erythrocyte volume;Transcapillary escape rate;F-cell ratio
数据来源: Karger
摘要:
In 88 patients with the nephrotic syndrome (NS) we estimated plasma volume (PV) with 131I-albumin (RISA) and calculated blood volume (BV) from PV and whole body hematocrit (Ht). To assess whether this method gives erroneously high values in the NS, the transcapillary escape rate of albumin (TER) and large vessel Ht/whole body Ht ratio (F-cell ratio) were measured in two subsets of these patients (n = 19 and 24, respectively). Although TER appeared to be increased and F-cell ratio slightly decreased in the NS as compared to normals, it could be calculated that overestimation of PV and BV from these sources will not exceed ± 1%. Taking these errors into account PV and BV appeared normal or increased in the NS (62.8 ± 9.6 and 94.9 ± 15.1 ml/kg vs. 56.0 ± 7.1 and 88.5 ± 10.1 ml/kg lean body mass in 51 normal controls). We conclude that PV can be measured reliably in the NS with 131I-albumin, and that even after appropriate corrections are made, PV and BV are normal or increased in most patients with th
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