Effect of the calcium entry blocker verapamil on renal ischemia
作者:
JAMES WOOLLEY,
GARY BARKER,
WAYNE JACOBSEN,
GARY GINGRICH,
STEVEN STEWART,
BURTON BRIGGS,
ROBERT MARTIN,
ROBERT MELASHENKO,
期刊:
Critical Care Medicine
(OVID Available online 1988)
卷期:
Volume 16,
issue 1
页码: 48-51
ISSN:0090-3493
年代: 1988
出版商: OVID
数据来源: OVID
摘要:
The ability of the calcium entry blocker verapamil to ameliorate the effects of renal ischemia was studied in ten sheep. Postanesthesia, bilateral cutaneous ureterostomies were placed in each sheep to facilitate urine collection and analysis. Both kidneys were made ischemic for one hour by occluding each renal artery. However, immediately before occlusion of the right renal artery, 0.05 mg/kg of verapamil was injected into the artery. Comparison of urinary creatinine excretion and urine volume for 72 h after reversal of ischemia demonstrated that those kidneys pretreated with verapamil had greater functional preservation (p< .05). In this study, verapamil appeared to provide protection against renal damage after an ischemic insult.
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