Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims
作者:
Anat Biegon,
Sheila Fieldust,
期刊:
Synapse
(WILEY Available online 1992)
卷期:
Volume 10,
issue 1
页码: 79-82
ISSN:0887-4476
年代: 1992
DOI:10.1002/syn.890100111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Norepinephrine (noradrenaline);Human brain;Immunohistochemistry
数据来源: WILEY
摘要:
AbstractAntibodies against tyrosine hydroxylase (TH, the rate‐limiting enzyme in norepinephrine synthesis) and dopamine β‐hydroxylase (DBH, the last enzyme in the synthesis) were used for immunohistochemical staining of human brain locus coeruleus sections, obtained postmortem form suicide victims and matched controls. Stain density over individual cells was quantified by a computerized, video‐camera‐based image analysis system. Mean stain density for TH was significantly lower (by about 30%) in the locus coeruleus of suicide victims. There was no difference between suicides and controls in DBH immunoreactivity or in the number of TH immunoreactive cells. Reduced TH availability, either genetically or environmentally determined, may contribute to the noradrenergic insufficiency postulated to occur in depression and the increased β‐adrenergic receptor concentrations observed in prefrontal cortex of suic
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