Assessment of stratum‐covariate interactions in Cox's proportional hazards regression model
作者:
Peter F. Thall,
John M. Lachin,
期刊:
Statistics in Medicine
(WILEY Available online 1986)
卷期:
Volume 5,
issue 1
页码: 73-83
ISSN:0277-6715
年代: 1986
DOI:10.1002/sim.4780050110
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Survival data;Proportional hazards regression model;Step‐down model selection;Stratification;Interaction;Optimal treatment selection
数据来源: WILEY
摘要:
AbstractWe assess stratum (e.g. treatment) interactions with covariates and with the baseline hazard function in the proportional hazards (PH) regression model for lifetime data. We consider models incorporating stratum interactions both with and without stratification of the risk sets in the likelihood function, and describe likelihood ratio statistics for tests of the presence of these interactions. We also present step‐down methods for building reduced models which include stratum‐specific parameters corresponding to covariates which interact with treatment. We apply PH models with such interactions to a clinical trial of DES in the treatment of prostate cancer to determine optimal treatment conditional on each patient's covaria
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