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N-Alkylation of Secondary Amine Tricyclic Antidepressants as a General Method for Their Quantitation by GC-MS-SIM Technique. Preparation of N-Ethyl Derivatives of Desimipramine, Nortriptyline, Protiptyline and Desmethyldoxepin

 

作者: N. Narasimhachari,   RobertO. Friedel,  

 

期刊: Analytical Letters  （Taylor Available online 1979）
卷期: Volume 12, issue 1  

页码: 77-88

 

ISSN:0003-2719

 

年代: 1979

 

DOI:10.1080/00032717908082520

 

出版商: Taylor & Francis Group

 

关键词: N-alkylation;N-ethyl derivatives;desimipramine;nortriptyline;desmethyldoxepin;protriptyline gcms-assay

 

数据来源: Taylor

 

摘要:

A simple method for the preparation of N-ethyl derivatives of secondary amino tricyclic antidepressants is described, using dimethylformamide diethyl acetal as the alkylating reagent. The GC data and electron impact and chemical ionization mass spectra of N-ethyl derivatives are presented. The use of these derivatives in the quantitation of plasma levels of these drugs in clinical studies is discussed.

 

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