Subacute toxicity of intravenous dimethyl sulfoxide in rhesus monkeys
作者:
J. C. de la Torre,
J. W. Surgeon,
T. Ernest,
R. Wollmann,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1981)
卷期:
Volume 7,
issue 1
页码: 49-57
ISSN:0098-4108
年代: 1981
DOI:10.1080/15287398109529957
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Daily iv doses of 3 g/kg dimethyl sulfoxide in a 40% solution were given to rhesus monkeys for 9 consecutive days. The monkeys were monitored before and after treatment for 4 mo for changes in blood chemistry, hematology, urine, and ocular, neurological, and cardiovascular systems. At the end of the study all animals were sacrificed and gross and microscopic pathological examinations were performed. No significant or long‐lasting changes were recorded in any of the parameters studied when these data were compared to those for saline controls.
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