Plasma and Lipoprotein Cholesterol in Rats FedL-Amino Acid-Supplemented Diets
作者:
C. Sérougne,
A. Rukaj,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1983)
卷期:
Volume 27,
issue 5
页码: 386-395
ISSN:0250-6807
年代: 1983
DOI:10.1159/000176710
出版商: S. Karger AG
关键词: Amino acids;Rat;Cholesterolemia;Lipoproteins
数据来源: Karger
摘要:
The effect of feeding amino acid-supplemented diets on plasma cholesterol concentration and distribution in the lipoproteins was studied on adult rats. A control diet (without any amino acid addition), and experimental diets supplemented with one of the following L-amino acids: lysine (10%), cystine (5%), methionine (1%), tryptophan (10%), valine (5%), and histidine (5 %), were given for 2–4 months. Rats fed the lysine-, cystine- and tryptophan-added diets exhibited constant weights throughout the experiment, whereas those fed the other amino acid-added diets showed body weight gains quite similar to control rats. Two amino acids were shown to lower plasma cholesterol concentration: lysine (by 30%) and tryptophan (by 35%); one amino acid increased it: cystine (by 46%). The cholesterol distriwbution in the lipoproteins was significantly modified, principally when rats ingested cystine-enriched diets: as compared to control rats, the cholesterol concentration in lipoproteins of hensity between 1.040 and 1.063, and in high density lipoproteins (HDL), was increased by 174 and 58%, respectivel
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