Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions
作者:
W-S Ahn,
J Yoo,
S-W Huh,
C-K Kim,
J-M Lee,
S-E Namkoong,
S-M Bae,
I P Lee,
期刊:
European Journal of Cancer Prevention
(OVID Available online 2003)
卷期:
Volume 12,
issue 5
页码: 383-390
ISSN:0959-8278
年代: 2003
出版商: OVID
关键词: Cervical cancer;EGCG;green tea extracts;HPV;polyphenon E
数据来源: OVID
摘要:
We investigated clinical efficacy of green tea extracts (polyphenon E; poly E and (−)-epigallocatechin-3-gallate [EGCG]) delivered in a form of ointment or capsule in patients with human papilloma virus (HPV) infected cervical lesions. Fifty-one patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups, as compared with 39 untreated patients as a control. Poly E ointment was applied locally to 27 patients twice a week. For oral delivery, a 200 mg of poly E or EGCG capsule was taken orally every day for eight to 12 weeks. In the study, 20 out of 27 patients (74%) under poly E ointment therapy showed a response. Six out of eight patients under poly E ointment plus poly E capsule therapy (75%) showed a response, and three out of six patients (50%) under poly E capsule therapy showed a response. Six out of 10 patients (60%) under EGCG capsule therapy showed a response. Overall, a 69% response rate (35/51) was noted for treatment with green tea extracts, as compared with a 10% response rate (4/39) in untreated controls (P<0.05). Thus, the data collected here demonstrated that green tea extracts in a form of ointment and capsule are effective for treating cervical lesions, suggesting that green tea extracts can be a potential therapy regimen for patients with HPV infected cervical lesions.
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