Analysis of multivariate parallel-line bioassay with composite responses and composite doses, using canonical corrlations
作者:
Weiying Yuan,
Anant M. Kshirsagar,
期刊:
Journal of Biopharmaceutical Statistics
(Taylor Available online 1993)
卷期:
Volume 3,
issue 1
页码: 57-71
ISSN:1054-3406
年代: 1993
DOI:10.1080/10543409308835048
出版商: Marcel Dekker, Inc.
关键词: Multivariate bioassays;Canonical variables;Composite response;Composite dose;Parallel-line bioassays;Relative potency;Incomplete block designs
数据来源: Taylor
摘要:
The use of a composite response to estimate the relative potency in a multivariate parallel–line bioassay is described by Finney (1). Occasionally a multivariate bioassay has multiple drugs also. Such a situation arises, for example, when a treatment contains several drugs. A procedure for combining multiple responses and combining multiple drugs is proposed in this paper, in order to obtain point and interval estimates of the relative potency. A composite response and a composite dose level for this purpose are obtained by using canonical analysis.
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