Clinical Pharmacokinetics and Pharmacodynamics of Repaglinide
作者:
Vibeke Hatorp,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 2002)
卷期:
Volume 41,
issue 7
页码: 471-483
ISSN:0312-5963
年代: 2002
出版商: ADIS
关键词: Antihyperglycaemics, pharmacokinetics;Cimetidine, drug interactions;Digoxin, drug interactions;Drug interactions;Repaglinide, drug interactions;Repaglinide, pharmacodynamics;Repaglinide, pharmacokinetics;Rifampicin, drug interactions;Theophylline, drug in
数据来源: ADIS
摘要:
Repaglinide is a novel, fast-acting prandial oral hypoglycaemic agent developed for the treatment of patients with type 2 diabetes whose disease cannot be controlled by diet and exercise alone. Although repaglinide binds to the sulphonylurea binding sites on pancreatic β-cells and has a similar mechanism of action, repaglinide exhibits distinct pharmacological properties compared with these agents. Following administration, repaglinide is absorbed rapidly and has a fast onset of dose-dependent blood-glucose lowering effect. The drug is eliminated rapidly via the biliary route, without accumulation in the plasma after multiple doses. Repaglinide is well tolerated in patients with type 2 diabetes, including elderly patients and patients with hepatic or renal impairment. The pharmacokinetic profile of repaglinide and the improvements in post-prandial hyperglycaemia and overall glycaemic control make repaglinide suitable for administration preprandially, with the opportunity for flexible meal arrangements, including skipped meals, without the risk of hypoglycaemia.
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