Protein Kinase Activity Associated with a Cell Cycle Regulated, Membrane-Bound Epstein-Barr Virus Induced Early Antigen
作者:
Malda M. Kocache,
Gary R. Pearson,
期刊:
Intervirology
(Karger Available online 1990)
卷期:
Volume 31,
issue 1
页码: 1-13
ISSN:0300-5526
年代: 1990
DOI:10.1159/000150128
出版商: S. Karger AG
关键词: Epstein-Barr virus;Monoclonal antibody;Early antigen;Protein kinase;Oncogene
数据来源: Karger
摘要:
An Epstein-Barr virus protein associated with the restricted component of the early antigen complex was characterized in this study. This protein was of particular interest because of its homology to polyoma middle T antigen and to the product of the bcl-2 oncogene. The results from this study reveal that this protein had a number of unusual properties in comparison with other polypeptides associated with the early antigen complex. For example, the synthesis of this membrane-associated antigen was regulated by the cell cycle, and its expression was compatible with cell survival. Functional studies reveal that immunoprecipitates containing this protein exhibited a threonine-serine-specific protein kinase activity. The results suggest that this protein might function in both the immortalization and replication cycles of this virus.
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