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Activation of a procarcinogen by reduction: Cr6+→Cr5+→Cr4+→Cr3+a case study by electron spin resonance (ESR/PMR)*

 

作者: Arthur Chiu,   Nancy Chiu,   Xianglin Shi,   Jefferson Beaubier,   NS Dalai,  

 

期刊: Journal of Environmental Science and Health, Part C  （Taylor Available online 1998）
卷期: Volume 16, issue 2  

页码: 135-148

 

ISSN:1059-0501

 

年代: 1998

 

DOI:10.1080/10590509809373504

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

Chromate is a human carcinogen. Since it does not form a covalent DNA adductin vitrounder physiological conditions, and is not mutagenicin vitroin the presence of cytochrome P450 preparations from liver, reduction of Cr6+by cellular reductants to lower oxidation states such as Cr5+, Cr4+is considered to be a critical step in the mechanism of carcinogenesis.

 

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