Synthesis of Thymidine Kinase (TK) in Epstein-Barr Virus-Superinfected Raji TK-Negative Cells
作者:
Jaroslav Roubal,
George Klein,
期刊:
Intervirology
(Karger Available online 1981)
卷期:
Volume 15,
issue 1
页码: 43-48
ISSN:0300-5526
年代: 1981
DOI:10.1159/000149213
出版商: S. Karger AG
关键词: Epstein-Barr virus;Thymidine kinase;Thymine-β-Z)-arabinofuranoside
数据来源: Karger
摘要:
Epstein-Barr virus (EBV) from P3HR-1 cells, but not from B95–8 cells, can induce the synthesis of thymidine kinase (TK) in TK-negative Raji cells. The synthesis of TK was slightly reduced, but not inhibited, when cells were cultivated in the presence of cytosine arabi-noside (ara-C). On the other hand, the synthesis of TK in ordinary Raji cells was enhanced in the presence of the drug. Thymine-β-D-arabinofuranoside (ara-T) was capable of reducing the conversion rate of thymidine to TdR nucleotides by extracts prepared from superinfected Raji TK-cells, but had no influence on TK activity in cell extracts from ordinary Raji cells and EBV-negative Ramos cells. This suggested a broader substrate specificity of the virally induced enzy
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