Alteration in colonic epithelial cell DNA associated with intestinal neoplasia: Selection of high risk patients
作者:
Joyce L. Matthews,
M. Glynn,
A. Parkins,
T. Cooke,
期刊:
British Journal of Surgery
(WILEY Available online 1987)
卷期:
Volume 74,
issue 1
页码: 23-25
ISSN:0007-1323
年代: 1987
DOI:10.1002/bjs.1800740108
出版商: John Wiley&Sons, Ltd.
关键词: Colon;DNA;cell kinetics;premalignancy
数据来源: WILEY
摘要:
AbstractThe proliferative activity of the colonic crypts of patients who are at high risk of developing colonic tumours has been assessed. Cells from the upper parts of the colonic crypts were collected at colonoscopy, and were stained for DNA by the Feulgen technique. Using a microdensitometer the DNA content of the cells was measured and a proliferative index calculated. Patients with single neoplasms had a proliferative index similar to controls although individual patients with hyperplastic mucosa could be identified. Patients with multiple neoplasms had an elevated proliferative index. These results may form the basis of a screening programme for colonic tumours.
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