Control of Regional Blood Flow by Endothelium‐Derived Nitric Oxide
作者:
Sheila Gardiner,
Alix Compton,
Terence Bennett,
Richard Palmer,
Salvador Moncada,
期刊:
Hypertension
(OVID Available online 1990)
卷期:
Volume 15,
issue 5
页码: 486-492
ISSN:0194-911X
年代: 1990
出版商: OVID
关键词: nitric oxide;endothelium;arginine;vasopressin;hemodynamics;Long Evans rats
数据来源: OVID
摘要:
The regional hemodynamic consequences of inhibiting vascular endothelial nitric oxide generation withNG-monomethyl-L-arginine (L-NMMA) were studied in conscious Long-Evans rats. Experiments were carried out in groups of chronically instrumented rats with intravascular catheters and pulsed Doppler probes to monitor regional blood flow. L-NMMA (0.3–300 mg/kg) caused a dose-dependent, long-lasting (5–90 minutes), and enantiomerically specific increase in mean blood pressure and also caused bradycardia. The increase in blood pressure was accompanied by a dose-dependent and long-lasting vasoconstriction in the internal carotid, mesenteric, renal, and hindquarters vascular beds that could be attenuated, in a concentrationdependent manner, by L-arginine but not by D-arginine. In contrast, L-arginine did not affect the pressor or vasoconstrictor effects of vasopressin. These results indicate that nitric oxide production by vascular endothelial cells contributes to the maintenance of blood pressure and to the control of the resting tone of different vascular beds in the conscious rat.
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