Factors Influencing Plasma Concentrations of Carbamazepine and Carbamazepine‐10,11‐Epoxide in Epileptic Children and Adults
作者:
Vera Lanchote,
Pierina Bonato,
Geraldo Campos,
Ismar Rodrigues,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1995)
卷期:
Volume 17,
issue 1
页码: 47-52
ISSN:0163-4356
年代: 1995
出版商: OVID
关键词: Carbamazepine;Carbamazepine-10,11-epoxide;Plasma levels;Dose ratios
数据来源: OVID
摘要:
Plasma carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) concentrations were measured in 160 epileptic patients in order to determine the effect of factors such as age, daily dosing schedule, formulation, and combination with other antiepileptic drugs on these concentrations in relation to the daily dose. The results showed that the CBZ plasma level/dose ratio was affected by all factors studied, whereas the CBZ-E plasma level/dose ratio was affected only by formulation and age. The ratio of CBZ-E to CBZ plasma levels (CBZ-E/CBZ) was affected by daily dosing schedule, age, and combination with other antiepileptic drugs. The present study demonstrated that many factors affect plasma CBZ/dose ratios, explaining the discrepancies observed in the literature.
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