Hepatitis B viral markers in severe viral hepatitis: Influence of steroid therapy
作者:
Harry B. Greenberg,
William S. Robinson,
C. Michael Knauer,
Peter B. Gregory,
期刊:
Hepatology
(WILEY Available online 1981)
卷期:
Volume 1,
issue 1
页码: 54-57
ISSN:0270-9139
年代: 1981
DOI:10.1002/hep.1840010109
出版商: W.B. Saunders
数据来源: WILEY
摘要:
AbstractIn our double‐blind randomized trial of methylprednisolone vs. placebo in severe viral hepatitis, 16 patients with hepatitis B (8 on steroid, 8 on placebo) were followed for at least 4 weeks. Four of the eight patients receiving methylprednisolone eventually died and all patients on placebo survived. Despite marked reduction in serum IgG in steroid‐treated patients, the decline in HBsAg titer and disappearance of Dane particle markers was the same in both treatment groups. A nonspecific depression of anti‐HBc was noted in patients given steroid. There is no evidence that corticosteroid therapy accelerates viral replication when the acute hepatitis is s
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