WNK4Intron 10 Polymorphism Is Not Associated With Hypertension
作者:
Helen Speirs,
Brian Morris,
期刊:
Hypertension: Journal of The American Heart Association
(OVID Available online 2004)
卷期:
Volume 43,
issue 4
页码: 766-768
ISSN:0194-911X
年代: 2004
出版商: OVID
关键词: kinase;hypertension, essential;genetics;polymorphism;sodium transport
数据来源: OVID
摘要:
Abstract—A polymorphism in intron 10 of the serine-threonine kinase with no lysine (K) 4 geneWNK4(G→A, base 1156666 on chromosome 17) has recently been associated with essential hypertension in a white American population. We have attempted to replicate this finding in a well characterized cohort of 184 unrelated hypertensive Australians of British extraction in which biological power was enhanced by them each having 2 hypertensive parents. Controls were 219 normotensive ethnically matched subjects whose parents were both normotensive. Genotyping was performed using the homogeneous MassEXTEND Assay. This showed a frequency of 0.10 for the minor allele in each group (P=0.88). Moreover, blood pressure, body mass index, sex, and plasma lipid levels were similar across genotypes. In conclusion, our study provides no support for an association of the intron 10 variant ofWNK4with essential hypertension in the Anglo-Australian population studied.
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