Studies of Coagulation and Platelet Functions in Heparin-Free Hemodialysis
作者:
P. Ivanovich,
C.G. Xu,
H.C. Kwaan,
S. Hathiwala,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 33,
issue 2
页码: 116-120
ISSN:1660-8151
年代: 1983
DOI:10.1159/000182924
出版商: S. Karger AG
关键词: Heparin-free;Hemodialyzer membranes;Platelet count;Platelet aggregation
数据来源: Karger
摘要:
Hematologic and coagulation studies were carried out during 12 heparin-free hemodialyses in 9 maintenance hemodialysis patients. Treatment employed a C-DAK 4000 cellulose acetate membrane hemodialyzer. Both hemodialyzer and blood tubing were periodically flushed with physiologic saline. No significant clotting of the hemodialyzers was encountered in uneventful dialyses. Platelet counts, platelet aggregation with ADP and epinephrine, antithrombin III and fibrinogen/fibrin degradation products were not significantly changed compared with pre-dialysis values. Fibrinopeptide A levels, elevated pre-treatment, demonstrated additional rise during dialysis. These findings support clinical experience that this anticoagulation-free method can be used safely and effectively to dialyze patients at risk for bleeding.
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