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Synthesis of (S)‐Nτ‐[D3] methylhistidine

 

作者: Sun‐Shine Yuan,   Alfred M. Ajami,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1984）
卷期: Volume 21, issue 1  

页码: 97-100

 

ISSN:0362-4803

 

年代: 1984

 

DOI:10.1002/jlcr.2580210111

 

出版商: John Wiley&Sons, Ltd.

 

关键词: deuterium;carbonyl diimidazole;(S)‐5‐Oxo‐7‐carbomethoxy‐5,6,7,8‐tetrahydroimidazo[1,5‐c]pyrimidine;(S)‐Nτ‐methylhistidine

 

数据来源: WILEY

 

摘要:

Abstract(S)‐Histidine methyl ester was converted on a 20 g scale to its Nα, Nπ‐cyclic urea by treatment with carbonyl diimidazole. The Nτposition was alkylated with [D3]‐methyl iodide and the product was hydrolyzed to give isomerically and isotopically pure Nτ‐[D3] methylhistidine, without significant loss of optic

 

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