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Identification of 5-(3,4-Dihydroxyphenyl)-5-Phenylhydantoin: A Metabolite of 5,5-Diphenylhydantdin (Dilantin1) in Rat Urine

 

作者: Tsun Chang,   R.A. Okerholm,   A.J. Glazko,  

 

期刊: Analytical Letters  （Taylor Available online 1972）
卷期: Volume 5, issue 4  

页码: 195-202

 

ISSN:0003-2719

 

年代: 1972

 

DOI:10.1080/00032717208069550

 

出版商: Taylor & Francis Group

 

关键词: diphenylhydantoin;metabolite;catechol;gas chromatography;mass spectrometry

 

数据来源: Taylor

 

摘要:

Using radioisotope tracer technics and GC-mass spectrometry, a new metabolite of 5,5−diphenylhydantoin present in rat urine has been dentified as 5-(3,k-dihydroxyphenyI)-5-phenylhydantoin. This catechol represented about 2% of the total metabolites excreted in rat urine folowing administration of diphenylhydantoin in the diet for over two weeks

 

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