Generation Mechanism of the Negative Endocochlear Potential during Early Stage of Anoxia
作者:
Jun Kusakari,
Masaaki Rokugo,
Junichi Kambayashi,
Eiichi Arakawa,
Kenji Ohyama,
Akira Hara,
Kazutomo Kawamoto,
期刊:
ORL
(Karger Available online 1983)
卷期:
Volume 45,
issue 4
页码: 195-202
ISSN:0301-1569
年代: 1983
DOI:10.1159/000275643
出版商: S. Karger AG
关键词: Negative EP;Anoxia;Diffusion potential
数据来源: Karger
摘要:
To investigate the generation mechanism of the –EP in anoxic cochlea, the perilymphatic space was perfused with solution of various K+ concentrations in 38 guinea pigs when the –EP was maximally reduced by anoxia. Although the perfusion of scala tympani and vestibuli with Ringer-Locke solution or that of scala vestibuli with 154 mM K+ solution did not have any effect upon the –EP, the potential was elevated to 0 mV when the scala tympani was perfused with 154 mM K+ solution. Furthermore, the elevation of the potential was less remarkable when the K+ concentration in perfusate was reduced. The level of the potential during perfusion was closely related to K+ concentration in perfusates. The present results strongly suggest that the –EP is the result of the K+ diffusion potential and this diffusion mechanism is performed through the organ o
点击下载:
PDF
(1799KB)
返 回