Intracellular Free Magnesium of Red Blood Cells in Patients with Renal Disease
作者:
Shunichi Kojima,
Masaru Kanashiro,
Tohru Sanai,
Masahito Imanishi,
Minoru Kawamura,
Yuhei Kawano,
Genjiro Kimura,
Mono Kuramochi,
Hiroshi Amemiya,
Teruo Omae,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 61,
issue 1
页码: 89-93
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186841
出版商: S. Karger AG
关键词: Magnesium;End-stage renal disease;Renal transplantation;NaK pump
数据来源: Karger
摘要:
While serum magnesium (Mg) level is increased in patients with end-stage renal disease (ESRD), it is decreased in renal transplant recipients (TR) receiving ciclosporin. This study was performed to examine the cation metabolism of red blood cells (RBC) in these patients. Intracellular free Mg was measured with 31P-nuclear magnetic resonance spectrometry, and ouabain-sensitive sodium (Na) efflux rate (Eos) was measured from the increase in RBC-Na concentration when RBC were incubated in the presence of ouabain. The ouabain-sensitive Na efflux rate constant (ERCos) was obtained by dividing Eos by RBC-Na concentration. RBC free Mg and ERCos were significantly higher in the TR group than in the ESRD group. There was a significant correlation beetween RBC free Mg and ERCos (r = 0.474, p < 0.01). These results support the views that the regulation mechanism for intracellular free Mg is different from that for extracellular Mg in patients with renal disease, and intracellular free Mg modulates Na pump activity of RBC.
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