Induction of Salicyluric Acid Formation in Rheumatoid Arthritis Patients Treated with Salicylates
作者:
Richard O. Day,
Danny D. Shen,
Daniel L. Azarnoff,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1983)
卷期:
Volume 8,
issue 3
页码: 263-271
ISSN:0312-5963
年代: 1983
出版商: ADIS
数据来源: ADIS
摘要:
Average steady-state serum salicylate concentrations and salicyluric acid (SU) formation rates were measured in 4 subjects with rheumatoid arthritis. After a salicylate washout period (1 month), the mean observed maximum formation rate of SU was determined by collecting frequent urine samples after a single oral dose of salicylate (35 mg/kg). The patients were then commenced on appropriate high dose salicylate therapy. Two and 5 weeks later, the mean observed maximum rates of SU formation were re-determined along with the average steady-state serum salicylate concentrations. Mean observed maximum SU excretion rates increased significantly between the single-dose study (0.96 ± 0.22 mg/kg/h) and the last dose of the high dose therapy at 2 weeks (1.65 ± 0.30 mg/kg/h; p < 0.01); however, there was no further increase at week 5. Similar increases in the theoretical maximum rate of SU formation (Vmax) were observed between the single-dose study and after 2 weeks of high dose salicylate therapy. Average steady-state serum salicylate concentrations showed no decline between weeks 2 and 5.High dose salicylate therapy leads to acceleration of the rate of SU formation in patients with rheumatoid arthritis and this occurs largely during the first 2 weeks of therapy.
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