Anaplastic Carcinoma of the Lacrimal Gland Presenting with Recurrent Subconjunctival Hemorrhages and Displaying Incipient Sebaceous Differentiation
作者:
Rand Rodgers,
Frederick Jakobiec,
Michael Gingold,
Albert Hornblass,
Wolf Krebs,
期刊:
Ophthalmic Plastic and Reconstructive Surgery
(OVID Available online 1991)
卷期:
Volume 7,
issue 4
页码: 229-237
ISSN:0740-9303
年代: 1991
出版商: OVID
关键词: Lacrimal gland anaplastic carcinoma;Sebaceous differentiation
数据来源: OVID
摘要:
Primary adenocarcinomas of the lacrimal gland rarely display sebaceous differentiation. An anaplastic lacrimal gland neoplasm manifesting this feature was excised from a 64-year-old man who initially appeared with recurrent painless subconjunctival hemorrhages. Globe displacement and tumor-induced hyperopia were later findings. Electron microscopic studies performed on the widely excised tumor documented prominent lipid vacuoles, desmosomes. scattered cytoplasmic filaments, and linear segments of basement membrane material. The patient refused radical surgery and instead opted for 6,000 rads of adjuvant radiotherapy. Eleven months postoperatively liver and bone metastases developed, but he was free of local orbital recurrence. Twenty-two months postoperatively he died from complications of his metastatic disease. This most unusual lacrimal neoplasm is discussed in terms of its initial signs and symptoms and its histopathology. When the current case is analyzed in combination with three earlier reports, there is evidence that primary lacrimal gland sebaceous carcinoma is probably among the most malignant orbital tumors due to its uniform early fatality.
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