Doxil-induced regression of pleuro-pulmonary metastases in a patient with malignant meningioma
作者:
Mila Travitzky,
Eugene Libson,
Igor Nemirovsky,
Irit Hadas,
Alberto Gabizon,
期刊:
Anti-Cancer Drugs
(OVID Available online 2003)
卷期:
Volume 14,
issue 3
页码: 247-250
ISSN:0959-4973
年代: 2003
出版商: OVID
关键词: Doxil;malignant meningioma;pleuro-pulmonary metastases
数据来源: OVID
摘要:
Metastatic meningioma is a rare disease, which has no effective chemotherapy. We report on a treatment of this condition with Doxil, a liposomal doxorubicin formulation. A 60-year-old woman with massive pleuro-pulmonary metastases from recurrent cranial meningioma was treated with Doxil (50–37.5 mg/m2) for 18 months with near-complete resolution of metastases and disappearance of pleural fluid. The only significant toxicities observed were stomatitis and hand–foot syndrome, which resolved with dose reduction and increase of dosing intervals. Doxil was cleared very slowly in this patient with a monoexponential half-life of 108 h. The patient remains in near-complete response for 6 months after treatment discontinuation. This is the first report on an effective chemotherapy in a patient with typical metastatic meningioma. The exact mechanism accounting for such an effective drug action is not clear, but may be related to a particularly high microvascular permeability to the liposome carriers in these metastatic lesions.
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