Investigation of Enterohepatic Bile Acid Circulation with [15N]Taurocholate
作者:
U.E. Rolle-kampczyk,
P. Krumbiegel,
Th. Richter,
期刊:
Isotopes in Environmental and Health Studies
(Taylor Available online 1995)
卷期:
Volume 31,
issue 3-4
页码: 241-246
ISSN:1025-6016
年代: 1995
DOI:10.1080/10256019508036265
出版商: Taylor & Francis Group
关键词: Bile acid circulation;nitrogen 15;organ function tests;taurine;taurocholate;tracer techniques
数据来源: Taylor
摘要:
[15N]Taurocholate has been prepared and used as a simple urine test substrate as a substitute for14C- and13C breath test substrates. [15N]Taurocholate was administered instead of [15N] glycocholate assuming that taurine is mainly used in the cholate cycle. Differences were found between healthy and diseased subjects, although deconjugated [15N]taurine was recovered in urine much less than expected. To get additional information on the actual excess of free taurine, [15N]taurine was administered orally in parallel investigations. Apparently, large fluctuations in the whole body taurine metabolism are responsible for the unexpected results.
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