首页   按字顺浏览 期刊浏览 卷期浏览 Investigation of Enterohepatic Bile Acid Circulation with [15N]Taurocholate
Investigation of Enterohepatic Bile Acid Circulation with [15N]Taurocholate

 

作者: U.E. Rolle-kampczyk,   P. Krumbiegel,   Th. Richter,  

 

期刊: Isotopes in Environmental and Health Studies  (Taylor Available online 1995)
卷期: Volume 31, issue 3-4  

页码: 241-246

 

ISSN:1025-6016

 

年代: 1995

 

DOI:10.1080/10256019508036265

 

出版商: Taylor & Francis Group

 

关键词: Bile acid circulation;nitrogen 15;organ function tests;taurine;taurocholate;tracer techniques

 

数据来源: Taylor

 

摘要:

[15N]Taurocholate has been prepared and used as a simple urine test substrate as a substitute for14C- and13C breath test substrates. [15N]Taurocholate was administered instead of [15N] glycocholate assuming that taurine is mainly used in the cholate cycle. Differences were found between healthy and diseased subjects, although deconjugated [15N]taurine was recovered in urine much less than expected. To get additional information on the actual excess of free taurine, [15N]taurine was administered orally in parallel investigations. Apparently, large fluctuations in the whole body taurine metabolism are responsible for the unexpected results.

 

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